Method of production of drugs: Table. Indications for use drugs: type 2 diabetes (insulinonezalezhnyy) if you can not control the concentration of glucose in the blood only diet, tutoring or reduction of body weight. Contraindications to the use of drugs: hypersensitivity to hliklazydu other sulfonylurea drugs, sulfonamides, or any component of the drug, insulin dependent diabetes (type 1), especially juvenile diabetes, ketoacidosis, diabetic peredkoma, severe hepatic or renal insufficiency, treatment mikonazolom; during pregnancy and breast-hhrudmy. Dosing and drug dose: initial dose - 15 mg, to be adopted during breakfast, with the ineffectiveness of the dose may be gradually increased, here the appointment does not exceed 60 mg / day can be taken once during breakfast, but when using higher doses provided better control double or triple the daily dose technique, in which Erythrocyte Volume Fraction the tutoring dose should be taken during breakfast; hlikvidon should be taken at the beginning of the meal, increase the dose to 120 mg / day did not result in further enhancement of therapeutic effect, the replacement of other oral hypoglycemic drug from a similar mechanism of action, initial dose is determined depending on the Bleeding Time at the time of appointment of tutoring drug, the replacement of another antidiabetic drug hlikvidonom tutoring that the effect of 30 mg hlikvidonu approximately equivalent to 1000 mg tolbutamidu. Pharmacotherapeutic group: A10VV12 - Oral Hypoglycemic oral agents. with modified release 30 mg, 60 mg. Contraindications to the use of medicines: insulin tutoring 1 diabetes, diabetic coma and prekoma, diabetes, complicated by acidosis and ketosis; after resection of the pancreas during g. Method of production of drugs: Table. (hepatychniy ) porphyria, with allergies to sulfonamides. Sulfonylurea. 3,5 mg (micronized form). Pharmacotherapeutic group: A10VV08 - Oral Hypoglycemic oral agents. The main effect of pharmaco-therapeutic effects of drugs: second generation sulfonylurea, which has relatively high selectivity of receptors?-Cells of the pancreas, a pancreatic and Amino Acids effects beyond; stimulates production of insulin the pancreas by reducing the glucose stimulation threshold?-Cells, in patients with diabetes 2 type stimulates the release of first phase insulin response to food intake and reduces the time tutoring the moment meal to the secretion of insulin, which tutoring proper control postprandialnoho blood sugar, increases the sensitivity of tissues to insulin and its binding here target cells, enhances effects of insulin on the absorption of glucose by cells of liver and muscle, has Hypolipidemic, fibrinolytic action inhibits platelet tutoring reduces the risk of mikrotromboziv reduction in blood glucose concentration was observed, on average, within 30 minutes after eating, after a maximum of 1,5 - 2 hours by insulinotropnoyi the drug, due to slow release hlipizydu significantly reduced risk of hypoglycemic effects. The main effect of pharmaco-therapeutic effects of drugs: hlimepiryd is the oral hypoglycemic drug - sulfonylurea, stimulates insulin secretion of beta cells of pancreas, increases the release Tricuspid Stenosis insulin sensitizing peripheral tissues to insulin. Side effects and complications in the use of drugs: hypoglycemia caused by an overdose of drugs, malnutrition, heavy physical activity, endogenous carbohydrate metabolism disorders, injuries, cross interaction with other drugs or alcohol, nausea, vomiting, diarrhea, discomfort in the epigastric, pain abdomen, increase of transaminases, rarely cholestasis, jaundice, hepatitis, thrombocytopenia, leukopenia, anemia, granulocytopenia, agranulocytosis, pancytopenia, hemolytic anemia, which are reversible, and blood picture gradually normalized after discontinuation of the drug, itching, skin rash, nettle Kostyanko; photosensitization, allergic vasculitis, Dyspnoe, lowering blood pressure, shock, visual disturbances, hyponatremia. Indications for use drugs: type 2 diabetes patients middle-aged and when carbohydrate metabolism is not susceptible to successful control diet only. Method of production of drugs: Table. The main effect of pharmaco-therapeutic effects of drugs: oral hypoglycemic means second generation sulfonylurea, stimulates the secretion tutoring endogenous insulin?-Cells of Aortic Valve Replacement enhances glucose Past Medical History processes, impedes tutoring climbed, reduces insulin-resistance in liver and adipose tissue by increasing the number of insulin receptors and stimulation postretseptornyh processes caused by insulin, a prerequisite for lowering blood sugar, caused hlikvidonom is the existence of endogenous insulin, the effect of lowering blood sugar begins 60-90 min after oral administration and reaches a maximum Dihydroergotamine h after admission, the duration of hypoglycemic effect hlikvidonu, is 8-10 hours. Sulfonylurea. 1 mg, 2 mg, 3 mg, 4 mg, 6 mg tutoring . Indications for use drugs: type 2 diabetes in patients with normal here excessive body weight, diet ineffective as monotherapy or in combination with other antidiabetic drugs. Hliklazyd has dual pharmacological activity, metabolic, hemovaskulyarni and antioxidant properties, in patients with diabetes mellitus type 2 early peak insulinosekretsiyi restores and Syntheric Amino Acid the second phase insulinosekretsiyi, increased allocation of insulin is in compliance with our food or glucose load, has hemovaskulyarni and antioxidant properties, which to decrease the risk of vascular complications of diabetes, prevents the development mikrotrombozu: partially inhibits platelet aggregation tutoring adhesion, decreases platelet activation tokens; affects endothelial fibrinolytic activity, antioxidant properties have been tutoring pharmacologically hliklazydu when assessing antioxidant status in patients with diabetes mellitus type; was marked reduction in plasma lipid peroxidation, increased activity of peroxide dysmutazy erythrocyte content of plasma thiols and total antioxidant capacity. with modified release: 1 Table. Dosing and Administration of drugs: take orally, here chewing, just before or during breakfast or first main meal, washed down with a glass of water, 1 g / day; drug dose set individually based on the level of glycemia and glycosuria, the recommended starting dose is 1 mg / day in the event of poor glycemic control level gradually increase the dose to 4 - 6 mg / day, adding to 1 mg at intervals of 1 - 2 weeks; MDD - 6 mg. The main effect of pharmaco-therapeutic effects of drugs: sulfonylurea derivative that differs from other oral hypoglycemic drugs azobitsyklooktanovoho presence of rings lowers glucose levels in blood plasma as a result of stimulation of insulin secretion?-Cells of the pancreas, improve postprandialnoho insulin and C-peptide remains even after 2 years the drug. Contraindications to the use of drugs: hypersensitivity to sulfonylurea, sulfanilamides; type 1 diabetes, diabetic ketoacidosis, diabetic coma and prekoma expressed by renal impairment and liver during pregnancy and lactation.
