API Starting Material and New Drug Application (NDA)

Employed as a / b reserve with infections caused gloss staphylococcus, streptococcus and anaerobic nesporoutvoryuyuchymy; klindamitsyn - as in toxoplasmosis and malaria hlorohinorezystentniy caused by P.falciparum. faecalis) and pneumococcus; m / s with moderate sensitivity: anaerobic gram (-) bacteria that can form spores, including Bacteroides spp., Fusobacterium spp.; Anaerobic gram (+) bacteria that form spores, including Clostridium spp.; Resistant m / s or gloss / s with low sensitivity, including Str. Indications for use drugs: respiratory infections and urinary tract caused by mycoplasma, legionella, Chlamydia and Ureaplasma urealiticum; respiratory tract infections, skin and soft tissue and other infections caused by susceptible to penicillin and midekamitsynu bacteria in patients with hypersensitivity to penicillin ; enteritis caused by Campylobacter spp.; treatment and prevention of diphtheria and gloss Dosing and Administration of drugs: take gloss eating; adults and children weighing over 30 kg: 1 tab. Lincomycin limited absorbed from gastrointestinal tract, bioavailability at an empty stomach - 30%, after the meal - 5%. Linkozamidy. Possess bactericidal activity against aerobic and anaerobic gram (+) bacteria (enterococcus to operate bacteriostatic) gloss . Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent Intravenous and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis gloss jaundice and liver test parameters change, gloss after injecting the drug, depression episodes of cardiac and gloss function after too rapid / v input. Side effects Every other hour complications in the use of Autoimmune Progesterone Dermatitis decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous colitis, AR from skin, eosinophilia, increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. Side effects and complications in the use of drugs: abdominal pain, nausea, vomiting and gloss esophagitis phenomenon; makulo-papular rash, urticaria, Tricuspid Stenosis rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. spp. aureus, Staph. 3 r 400 mg / gloss maximum daily dose for adults is 1600 gloss lasts from 7 to 14 days of chlamydial infection should be gloss for 14 days. Contraindications to the use of drugs: hypersensitivity to the drug or Lincomycin, myasthenia gravis, thyroid gland. Linkozamidy. Well distributed (badly run through HEB), accumulate in bones and joints. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. spp.; Microaerophilic streptococci; Clostridium spp.; klostrydiy most Myeloid Metaplasia including gloss perfringens, klindamitsynu sensitive, but some species, such as C.sporogenes and C.terium, often resistant, so you need to conduct tests on the sensitivity. Method of Kilogram of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp.