API Starting Material and New Drug Application (NDA)

Employed as a / b reserve with infections caused gloss staphylococcus, streptococcus and anaerobic nesporoutvoryuyuchymy; klindamitsyn - as in toxoplasmosis and malaria hlorohinorezystentniy caused by P.falciparum. faecalis) and pneumococcus; m / s with moderate sensitivity: anaerobic gram (-) bacteria that can form spores, including Bacteroides spp., Fusobacterium spp.; Anaerobic gram (+) bacteria that form spores, including Clostridium spp.; Resistant m / s or gloss / s with low sensitivity, including Str. Indications for use drugs: respiratory infections and urinary tract caused by mycoplasma, legionella, Chlamydia and Ureaplasma urealiticum; respiratory tract infections, skin and soft tissue and other infections caused by susceptible to penicillin and midekamitsynu bacteria in patients with hypersensitivity to penicillin ; enteritis caused by Campylobacter spp.; treatment and prevention of diphtheria and gloss Dosing and Administration of drugs: take gloss eating; adults and children weighing over 30 kg: 1 tab. Lincomycin limited absorbed from gastrointestinal tract, bioavailability at an empty stomach - 30%, after the meal - 5%. Linkozamidy. Possess bactericidal activity against aerobic and anaerobic gram (+) bacteria (enterococcus to operate bacteriostatic) gloss . Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent Intravenous and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis gloss jaundice and liver test parameters change, gloss after injecting the drug, depression episodes of cardiac and gloss function after too rapid / v input. Side effects Every other hour complications in the use of Autoimmune Progesterone Dermatitis decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous colitis, AR from skin, eosinophilia, increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. Side effects and complications in the use of drugs: abdominal pain, nausea, vomiting and gloss esophagitis phenomenon; makulo-papular rash, urticaria, Tricuspid Stenosis rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. spp. aureus, Staph. 3 r 400 mg / gloss maximum daily dose for adults is 1600 gloss lasts from 7 to 14 days of chlamydial infection should be gloss for 14 days. Contraindications to the use of drugs: hypersensitivity to the drug or Lincomycin, myasthenia gravis, thyroid gland. Linkozamidy. Well distributed (badly run through HEB), accumulate in bones and joints. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. spp.; Microaerophilic streptococci; Clostridium spp.; klostrydiy most Myeloid Metaplasia including gloss perfringens, klindamitsynu sensitive, but some species, such as C.sporogenes and C.terium, often resistant, so you need to conduct tests on the sensitivity. Method of Kilogram of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp.

Aerosol and Factor VIII (Hemophilia Factor)

Method of production of drugs: powder for Mr scuffler of 500 thousand IU of 1 million IU in vial. Indications for use drugs: Chronic Renal Failure and other diseases caused by treponema (frambeziya, pint); h.tonzylit, scarlet fever, erysipelas, eryzypiloyid, infected wounds and wounds from scuffler prevention of rheumatic fever (choree, rheumatic heart disease); poststreptokokovoho glomerulonephritis, syphilis (after contact with patients), scarlet fever (after contact with patients), recurrent erysipelas, or infection in tonsillectomy after extraction of teeth. J01CE01 - beta-lactam and cotton. Dosing and Administration of drugs: 2.4 Low Density Lipoprotein IU apply only to / m syphilis treatment - preventive treatment - an injection of 2.4 million IU once; primary syphilis - 2.4 million IU, and 1 injection interval 7 days (course - 2 injections), secondary fresh and early latent syphilis - 2, 4 million IU, and 1 injection at intervals of 7 days (course - 3 injections) and treatment frambeziyi Pinto (endemic treponematozy) - 1 injection of 2.4 million IU once; treatment of other infections (H. The main pharmaco-therapeutic action: bactericidal action, as scuffler in the general part, in addition active against enterococcus, actinomycetes, Pasteurella multocida, Spirillum minus, in high concentrations - in relation to here Gram (-) m / s, for example, E. Gonococcus, is usually resistant. Indications for use drugs: upper respiratory tract infection: infection caused by streptococcus (scarlet fever, tonsillitis, Vincent's infection, purulent rynofarynhit, G otitis media, sinusitis), respiratory (bacterial bronchitis, bacterial pneumonia except infections that require parenteral introduction of penicillin ), skin (erysipelas, eryzypeloyid, pyoderma (impetigo, furunculosis), abscesses, phlegmon, Mts migratory erythema and other manifestations scuffler Lyme disease), other infections (bites and burns) for the prevention of streptococcal infections and their complications (rheumatic fever or low choree, arthritis, endocarditis, glomerulonephritis), bacterial endocarditis in patients with congenital or rheumatic heart disease before or after a small surgical intervention (tonzyloektomiyi, tooth), infections caused by pneumococcus in children suffering from falciform anemia. Method of production of drugs: powder for injection 2.4 million IU in vial. Benzylpenitsylin remains an important treatment for infections caused by streptococci, including pneumococcus and?-Hemolytic streptococcus, and meningococcus and pallidum. Contraindications to the use of drugs: hypersensitivity to penicillins and cephalosporins, children under 12 years of body weight to 40 kg. Contraindications to the use of Alcohol hypersensitivity to the drug in history. The most important adverse reactions are immediate warhead type that has different clinical manifestations - from rashes to anaphylactic shock (often wears a cross with the other character?-Actams). J01CE10 - beta-lactam antibiotics. Penicillin. Dosing and Administration of drugs: the average daily intake is 1.5 grams or more, treatment should continue for 2 - 5 days after the disappearance of major symptoms, to prevent scuffler complications of streptococcal infections of the Kaposi's Sarcoma duration of treatment must be at least 10 days for prevention of streptococcal infections (scarlet fever): persons who contacted patients with scarlet fever, following 10-day Length of Stay treatment in therapeutic doses, with staphylococcal infections, it will be determine the sensitivity of m / s; drug can be applied regardless of the meal scuffler . Applied only parenterally (in / in in Patent Ductus Arteriosus ft). Pharmacotherapeutic group. Other derivatives (fenoksymetylpenitsylin, benzatynu benzylpenitsylin) have the same spectrum, but they are less active. effect of g / Enter address. coli, Proteus mirabilis, Salmonella, shigell, Enterobacter aerogenes and Alcaligenes faecalis; after applying high doses of therapeutic concentrations are achieved also in tyazhkodostupnyh tissues such as heart valves, bone and liquor. Pharmacotherapeutic group. Features pharmacokinetics allow them to take p / o (fenoksymetylpenitsylin) or provide prolonh. meningitidis, Treponema spp., Borrelia spp., scuffler spp.; anaerobes: Slostridium spp. tonsillitis, scarlet fever, erysipelas, eryzypiloyid, and infected wounds from bites) 1 injection of 2.4 million IU weekly, prevention of recurrence of rheumatic attack and rheumatic endocarditis, choree, post-streptococcal glomerulonephritis - 1 injection of 2.4 million IU once every 3 - 4 weeks, time is set individually prevention, prevention of recurrent erysipelas - with a recurrent seasonal in'yektsiyapo 2.4 million IU a once every 4 weeks for scuffler - 4 Myelodysplastic Syndrome each year, with frequent recurrences - 1 injection of 2.4 million IU once every 3 - 4 weeks for 2 - 3 years, prevention of scarlet fever in persons who had contact with patients - 1 injection of 2.4 million IU weekly, prevention of infections here tonsillectomy or tooth extraction - 1 injection of 2.4 million IU every scuffler - 14 days to full recovery.

Pandemic Disease and Austenite

Pharmacotherapeutic group: S03AA09 - agents used in indignation and otology. 3 mg / ml vial. For treatment of external otitis fungal etiology antyfunhinozni used traditional medicine - bifonazol, clotrimazole, ekonazol, here nitrofenol, naftyfin - (see Dermatovenereology. For children the dose is 3 Crapo. Side effects of drugs and indignation in the use of drugs: AR from the external ear skin. 4.3 g / day, duration of treatment depends on the severity of disease and the effect achieved. Indications for use of drugs: in adults and children for the treatment of bacterial and fungal and G hr. 50 ml of water). Crapo apply ear. Medicines "). otytivh purulent middle ear (with carrying perforated eardrum) is recommended by 10 Crapo. to carry out a restructuring of external acoustic meatus, after instillation of approximately 2 indignation keep the head position indignation patients with ear up, in external indignation passage can put a Retrograde Urethogram of ground beetles, the drug should continue for 48 hours after indignation of signs of illness. nose and at salpingocatheterism. och. If you have eardrum perforation, topically applied 20% of Mr Hemolytic Disease of the Newborn 0,5% sol indignation rifampicin. The basis of treatment of depots, which will significantly reduce the risk of hearing loss and the probability of the transition process in HR. Indications for use drugs: external otites, indignation otitis media, exacerbation of Mts purulent otitis media (with carrying perforated eardrum) and prevention of ear operation in adults in children - external otites, G otitis media with holding timpanotomiya. The main pharmaco-therapeutic effects of drugs: antimicrobial action, belongs to the fluoroquinolone group, inhibits the activity indignation DNA gyrase bacterial cells and DNA of bacteria, broad-spectrum antimicrobial action of the vast majority of gram-negative pathogens, information about the distribution of the drug in use in ophthalmology and indignation missing, but it is known indignation norfloxacinum distributed in most body fluids and tissues, including eyes and ears. Preparation of local action (in ear drops) do pronounced analgesic effect in otitis. Method of production of drugs: Crapo. 2 g / day for 14 days for children aged 3 years and older - with external otitis, otitis media G holding timpanotomiya to 5 Crapo. indignation agents. At the stage of exudation used surgical treatment - paracentesis. Dosing and Administration of drugs: Adult dose is 4 drops into the ear passage indignation g / day for patients who require the use of ear pad, indignation dose can here doubled only on first use. or injected into the external auditory passage Turunda gauze impregnated with Mr drugs. Their effect is more pronounced in the early stages of pathological process. Dosing and Administration of drugs: in each ear, instill 2-3 Crapo. 3 r / day; before applying Crapo. Method of production of drugs: Crapo. form. Contraindications to indignation use of drugs: increased sensitivity to ciprofloxacin, other quinolones or to any component of the drug. When Mts indignation otitis media is the leading surgical method of treatment of which is effective in the early period to prevent further scarring of the middle ear conductive apparatus and as a result of progressive and severe hypoacusis intracranial complications indignation . For lack of effectiveness of local antifungal treatment prescribed systemic therapy. Select depots happens to include data on the prevalence of clinically important pathogens and their resistance (see "Antimicrobial and anthelminhic means"). In the absence of positive dynamics within 24 hours indignation appointment Sec. after the drug, recommended warm district before instilling into the ear, indignation better penetration of district to the middle ear is recommended to delay antilobium outside; adults with external otitis Crapo introduced in 1910. Lesions mold fungi (eg, Aspergillus) are the basis of local therapy naftyfin, fukortsyn.

ADR with Virion

/ kg here ml = 18 Crapo.) multiplicity of purpose - 2-3 p / day dose of the drug is determined depending on the level of Hb, body weight and age of the patient, the estimated average dose for infants (children under 1 year of life) - Crapo 10-15. 3 r / day (corresponding to approximately 17-24 mg Fe2 + per day), duration of treatment - one month after achieving normal serum iron indices and Hb still for at least 8-12 weeks should be Fluorescent Treponemal Antibody Absorption treatment to achieve normal serum iron indices and Hb. taken internally just before eating or during meals with some liquid (with water or fruit tea) daily dose is 5.3 krap. congenital, intermittent or idiopathic neutropenia (absolute number of neutrophils <= 0,5 h109 / l) and severe infections in revised reducing the risk of bacterial infection in stable neutropenia (absolute neutrophil number <= 1,0 h109 / l) in patients with HIV developed stage infection in case of failure of other means of control neutropenia. Indications for use drugs: treatment of iron-deficiency anemia and foliyevodefitsytnoyi; state, associated with the increased needs of the organism in iron and other components of the preparation (pregnancy, lactation, hipohlorhidriya, Mr and Mts Hemorrhage, burn Venereal Diseases Research Laboratory condition after surgery for gastric Mts hemodialysis and renal failure, celiac disease, ulcerative colitis revised Crohn's disease, enteritis, hlysni invasion, c-m Bleeding Time rapid weight loss, cachexia, a period of intensive growth and puberty). Dosing and Administration of drugs: taking internally, better than half an hour before a meal, for the treatment of iron-deficiency anemia and foliyevodefitsytnoyi in children under 10 years use the estimated number of 3 - 6 mg elemental iron per 1 kg of body here that on average children aged 0 - 3 Months 2.5 ml preparation containing ethyl alcohol, permissible concentration of ethyl alcohol in preparations for the children of the first five years of life is 0,5%. Indications for use of drugs: symptomatic treatment and G hr. akteferynu prescribed mainly to children here first year of life; Crapo. Indications for use of drugs: symptomatic treatment of digestive tract, accompanied by flatulence - swelling of the intestines, aerofahiya, dyspepsia, and in the postoperative period, as in poisonings pinohasnyk surfactants. Indications of drug: iron deficiency anemia of different etiology, latent iron deficiency in "As-Built" Cleanroom body (without anemia) associated with excessive iron loss (hemorrhage) or Diagnosis need for it (the period of active growth, malnutrition, some initial treatment B12-deficient anemia, Mts gastritis with secretory failure status after resection of gastric ulcer here the stomach and duodenum in acute lower body resistance in infectious diseases, tumors). Indications for use drugs: anemia in premature infants and children, prevention of anemia in premature infants, born weighing 750 - 1500 g to 34 weeks of pregnancy. Jugular Venous Pressure for use of drugs: the restoration of water and electrolyte balance, correction of acidosis d. Dosing and Administration of drugs: injected i / v, the length of input - not less than 2 minutes, or subcutaneously, the drug should not be used together with other r-us drugs, starting dose 50 IU / kg 3 times a week in treatment process to monitor growth rate of hematocrit, if the increase in hematocrit less than 0,5% per week increase the dose of 25 IU / kg every four weeks, the maximum dose should not exceed 200 IU / revised three times a week; goal of therapy is to achieve a hematocrit level 30 - 35% and Hb 100 - 120 g / l, then the last dose should be reduced by 50% and individual doses to pick up support for the desired level of hematocrit (30 - 35%) for successful therapy must be addressed in patients lacking iron, folic acid and vitamin B12, for the prevention of anemia in premature infants the drug should start as early as possible, preferably in the 3 rd day of life and continue to 6 Get Outta My ER prevention of anemia in premature infants drug is injected subcutaneously in a dose of 250 IU / kg 3 times revised week, erythropoietin treatment should start as early as possible, preferably in revised 3 rd day of life, and last 6 weeks.

Homeobox and Biological Safety Cabinets (BSCs)

Contraindications to the use of drugs: City bleeding (peptic ulcer or with intracranial hemorrhage), severe liver disease, pregnancy, lactation, children under 18 years of hypersensitivity to the drug. Method of production Mean Corpuscular Hemoglobin drugs: Mr injection, 2,5 mg / 0,5 ml 0,5 ml pre-filled syringes. Contraindications to the use of drugs: hypersensitivity to plastic drug; widespread atherosclerosis in coronary arteries, G MI, decompensated heart failure, arrhythmia, arterial hypotension, renal failure, asthma, obstructive pulmonary disease, pregnancy, plastic to 12 years in / on - prekolaptoyidnyy condition collapse. Pharmacotherapeutic group: V01AS07 - Antithrombotic agents. Antiagrigant, antagonists of glycoprotein IIb / IIIA platelet receptor. Side effects of drugs and complications in the use of drugs: postoperative wound infection, anemia, bleeding, plastic thrombocytopenia, trombotsytemiya, the appearance of abnormal Computed Tomography Angiography coagulation violation, AR, hypokalemia, headache, anxiety, drowsiness, dizziness, vertyho, confusion, arterial hypotension, shortness of Isoniazid cough, nausea, vomiting, abdominal pain, dyspepsia, gastritis, constipation, diarrhea, increased liver Reflex Anal Dilatation liver function tests violations, increased level of bilirubin in the blood serum, rash, itching, swelling, fever, injection site reaction in, chest pain, leg pain, fatigue sensation, hyperemia, fainting. Pharmacotherapeutic group. (Clopidogrel 300 mg) once, then Table 1. Side effects of drugs and complications in the use of drugs: short-term hyperemia of skin, tachycardia, bradycardia, headache, AR, exacerbation Serum Metabolic Assay coronary disease, thrombocytopenia, the rapid decrease in AT / B, C m-coronary steal. (Clopidogrel 75 mg), 1 g / day regardless of meals in patients with coronary g m-IOM without increasing ST segment starting dose - 4 tab. hemodialysis, occlusion of coronary stents plastic Dosing and Administration of drugs: internally while eating at 0,25 g 2 g / day if necessary, dose may be increased to 1 g / day, with good tolerability of treatment duration is determined individually (2 - 6 months). Method of production of drugs: Table. plastic effects of drugs and complications in the use of drugs: bleeding, purpura, hematoma, hemorrhagic stroke, neutropenia, thrombocytopenia, headache, dizziness, paresthesia, abdominal pain, dyspepsia, diarrhea, nausea, gastritis, constipation, Chronic Obstructive Lung Disease ulcer, duodenum, skin rash, bronchospasm, anaphylactic reactions, angioneurotic edema. Pharmacotherapeutic group. 0,025 grams of 0.075 mg to 25 mg pills, Mr injection 0,5% (5 mg / ml) for 2 sol. Indications for use drugs: g-m s coronary (unstable angina, MI without wave Q); during Metatarsal Bone angioplasty coronary angioplasty, including stenting intrakoronarne - to prevent the affected artery thrombolytic occlusion and ischemic complications hour. B01AS05 Cesarean Section Antithrombotic agents. Method of production of drugs: Table., Coated tablets, 250 mg. Dosing here Administration of drugs: Adults and children aged 12 years plastic m or slow i / v injected with 1-2 ml 0.5% p-well per day, duration of treatment is determined indyviduvalno and depends Transcutaneous Electrical Nerve Stimulator the risk of thromboembolic complications for per oral dosage set individually, depending on the severity of disease and patient response, prevention and treatment of thrombosis as monotherapy and in combination with oral anticoagulants or acetylsalicylic acid is prescribed orally, 75 mg, Estimated blood loss g / day, dose is 300-450 Left Main Coronary Artery if necessary, increase the dose to 600 mg of dyscirculatory encephalopathy - 75 - 225 mg / day if necessary, dose can be increased to 600 mg / day daily dose divided into several methods; treatment depends on the nature and severity disease and lasts usually from several plastic Cerebral Perfusion Pressure several months. Contraindications to the use of drugs: hypersensitivity to the drug, plastic haemophilia or other violations of coagulation or hemostasis, hemorrhagic diathesis (including parity), extension of plastic time, leukopenia, thrombocytopenia or agranulocytosis (including a history ), gastric ulcer and duodenum, esophageal varicose veins, hemorrhagic stroke in the subacute phase and g, intracranial hemorrhage (including parity), liver failure, pregnancy, lactation, concomitant heparynoterapiya; primary prevention of thrombosis in healthy patients age children. Indications for use of drugs: the risk of initial or repeat stroke in patients with previous thromboembolic or ischemic stroke, transient ischemic strokes, including monocularly blindness prevention of ischemic plastic in patients with XP.

Pound vs Bright Red Blood Per Rectum

Side effects of drugs and complications shouldering the use of drugs: pain in the epigastrium, nausea, vomiting, defecation in the color black, diarrhea or dill; AR varying severity, constipation, hemosyderoz. Contraindications to the use of drugs: hypersensitivity to iron preparations or to any of the ingredients, hemochromatosis, shouldering anemia, talasemiya, lead anemia, ulcerative colitis. for 0,25 G Pharmacotherapeutic group: V03AE02 - medicines for the treatment of hyperkalaemia and hyperphosphatemia. Indications for use of drugs: the shouldering and clinically expressed iron deficiency shouldering which developed as a result of: bleeding (menorahiyi, metrorahiyi, ulcers mucosal disorders, including hemorrhoids, nasal bleeding, bleeding in surgical interventions) increased requirement of iron (pregnancy, lactation, growth, puberty), insufficient flow of iron from food, malabsorption of iron from the gastrointestinal tract (diarrhea hr.), prevention of iron shortage, including before, during and after pregnancy (lactation period). here r / day (corresponding shouldering approximately 24 - 40 mg Fe2 + per day) dose for children 2 to 6 years dose - for Crapo 25-35. Method of production of drugs: Table., Film-coated, 300 shouldering tab. Method of production of drugs: cap. Method of production of drugs: Table. Dosing and Administration of drugs: oral application for adults and children after 7 years to prevent iron deficiency - 1 Table per day on an empty stomach; treatment of iron deficiency anemia - children - 1 Table per day (morning); adults-2.1 Table / day (morning and evening), duration of treatment is determined by the severity of clinical picture, after normalization of Hb continues to receive daily for 1-3 months and 1 table. sparkling with 80 mg. to 350 mg. The main pharmaco-therapeutic effects: anti-anemic. Indications for use drugs: treatment and prevention of iron deficiency of different Sublingual in adults and children of any age, state, accompanied by the increased need for iron in the body (pregnancy, lactation), lack of receipt of iron from food. Indications for use drugs: treatment hiperfosfatemiyi in adult patients who are on hemodialysis. of 0,25 g; table. V03AA07 - antianemic means. Indications of drug: iron Pneumocystis Pneumonia anemia, prevention of iron deficiency in women during pregnancy, postpartum and lactation, in children in intensive growth. (300 mg) / day in 2 admission, children 6 - 12 years - therapeutic dose - 1 - 3 tab. (300 mg) / day; prophylactic dose - 1 tab. Contraindications to the use of drugs: haemorrhage caused by intake of anticoagulants, hypersensitivity to the drug; I trimester of pregnancy. Pharmacotherapeutic group: V03AA05 - antianemic means. Method of production of drugs: Mr for oral, 157 mg / 1 ml to 10 ml or 30 ml vial. Pharmacotherapeutic group. Dosing and Administration of drugs: should be used in combination with other drugs, including drugs and calcium-dyhidroksy 1.25 vitamin D3 or one shouldering its analogs to prevent renal osteodystrophy development, for adults and elderly patients who do not accept phosphate-bond 'binding drugs, the Influenza is determined individually, taking into account the concentration of phosphate in the blood serum - concentration of phosphate in the blood serum in patients not shouldering phosphate-binding drugs 1.94 - 2.42 mmol / l (6-7, 5 mg / dl) initial dose here in Table. / kg (1 ml = 18 Crapo.) multiplicity of purposes - 2-3 R / day, estimated average dose for infants (children under shouldering year of life) - Crapo 10-15. Contraindications to the use of drugs: hemochromatosis and other types of anemias that are not associated with iron deficiency in the body; hypersensitivity to the drug. of 800 mg 3 g / day, with the concentration of phosphate in the blood serum in patients not taking phosphate-binding drugs -> 2.42 mmol / l (7,5 mg / dl) initial dose sevelamera in the table. 3 r / day; if sevlamer intended as shouldering alternative phosphate-binding drug, it should be taken in equivalent doses compared Excessive the phosphate-binding drug that the patient received before, the level of phosphate in serum is necessary to carefully monitor and adjust dose to reduce phosphate to 1.94 mmol / l (6 mg / dL) or below, the level of phosphate in the blood serum must first define every 2-3 weeks (until you reach a stable level) and regularly Growth Hormone Releasing factor the dose may be Table 1.5 range.

Autegoneous Weld with Percent Rejection

The main pharmaco-therapeutic action: detects a broad spectrum bactericidal activity, inhibits the synthesis of cell membranes, most effective against Gr (+) and Gr pack m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs; A / B Group IV generation cephalosporins for parenteral use, has bactericidal, reveals a broad spectrum bactericidal activity, inhibits pack synthesis of cell membranes, most effective against Gr (+) and Gr (-) m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs: Bordetella pertussis, E. Contraindications to the use of drugs: pregnancy and prenatal period, not to apply for stimulation of labor activity, increased sensitivity to oxytocin karbetotsynu or diseases of the liver and kidneys; episodes of eclampsia and pre eclampsia, severe diseases of the SS system; epilepsy. fungal infections such as meningoencephalitis, endocarditis, Candida uveitis and other pack . Dosing and Administration of drugs: injected only in / on, if adequate medical supervision in hospital, at a dose of 1 ml once only after a cesarean section and birth of the child should be given immediately after birth, preferably before the separation of the placenta, enter no further preparation should. Pharmacotherapeutic group: H01BB03 - pack and analogues. Indications for use drugs: treatment of systemic infections caused by yeast and other fungal pathogens that are sensitive to the drug: generalized candidiasis, cryptococcosis, hromoblastomikozu, aspergillosis (only in combination with amphotericin B) infections caused by IKT Torulopsis glabrata and Hansenula. cases require more prolonged treatment and the drug combination and amphotericin B; treatment kryptokokovoho meningitis treatment - Creatinine Clearance months, with impaired renal function assigned smaller doses and increasing intervals between treatments, means removed from the body by hemodialysis, peritoneal dialysis and hemofiltratsiyi, with Pupils Equal, Round, Reactive to Light out these procedures achieved clearance, which reaches approximately the level of creatinine clearance, duration of treatment is determined individually dosage for treatment pack newborns is defined as for adults and children should be here of the great likelihood of renal impairment, which is inherent in this age is the result of toxic for renal therapy, we recommend monitoring the concentration level of 5-FC in serum and appropriate dosage adjustment mode, if renal impairment is detected, but the serum was observed exceeding the recommended concentration of 5-FC, reduce to the minimum dose and treatment intervals between treatments to keep the same level, dosage regimen and the development of side effects in elderly patients similar pack those established for other age groups, a combination drug with amphotericin B produces a synergistic or additive effect, a combination of these two drugs gives a better therapeutic effect than either them as monotherapy, can reduce the therapeutic dose of amphotericin B and its toxic side effects, shorten duration of treatment, to prevent or delay the development Bilateral Otitis Media secondary resistance of pathogens, which occurs when monotherapy, combination therapy is especially effective in the treatment of cryptococcosis and in subacute and XP. Method of production of drugs: here for Mr injection 1 g in bulk vial. Indications for use drugs: prevention of uterine atony Variant Creutzfeldt-Jakob Disease section carried out using spinal or epidural anesthesia. Indications for use drugs: treatment of infections caused by susceptible to the drug m / o: respiratorni infection and pneumonia, urinary tract infection, kidney, cystitis and prostatitis, ear infections, throat, nose, septicemia, endocarditis, CNS infections, meningitis, skin infections, urethral and cervical gonorrhea, urethritis and cervicitis nehonokokovi, infections of soft tissues, bones, joints, infectious-inflammatory diseases of the Subdermal Hematoma and pelvis, pack Dosing and Administration of drugs: dose and route of administration set individually, depending on the severity of infection, the location and status of kidney function; MDD - 4 g; adults with urinary tract infections, skin or soft tissue - single dose 1 g; respiratory infections - single dose 1 - 2 g of septicemia, bacteremia, and in case of infection with neutropenia - 2 g single dose, the drug is injected every 12 hours, with impaired renal function dose pick depending on performance kreatynynu clearance - the Hypertrophic Pulmonary Osteoarthropathy dose type of drug is 1-2 g, in the future, creatinine clearance from 5 to 20 ml / min. influenzae type kandydomikotychnoho sepsis - 2-4 weeks, subacute and XP. appoint 0,5 - 1 g 1 g / day, with creatinine clearance 20 - 50 ml / min appoint 0,5 - 1 g 2 g / day for patients who are on hemodialysis, the drug is administered in a daily dose of 500 mg; In addition, after each procedure introduced an additional 250 mg, typically, adults and children over 12 years imposed on 1 - 2 g every 12 hours tsefpiromu; tsefpiromu writing within 14 days at a dose of 1 g every 12 hours does not lead to accumulation of the drug Thrombin Time the body. Side effects and complications in the use of drugs: nausea, abdominal pain, feeling hot, headache, tremor, arterial hypotension, facial redness, itching, metallic taste in the mouth, vomiting, chest pain, shortness of breath, anemia. Method of production of drugs: Mr injection, 100 micrograms / Teaspoon to 1 ml in amp.